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ДИАКОН

BACKGROUND
Cystatin-C is an inhibitor of cysteine proteases with a molecular mass of 13 kDa. Due to its physical
properties it is freely filtrated through the glomeruli then reabsorbed and almost completely catabolized by
the proximal tubular cells. It is a normal component of urinary proteins in very low concentration. Recent
studies showed that elevated levels of urinary cystatin-C (u-CYSC) reliably indicates tubular dysfunction.

AIMS
Because commercial u-CYSC test is not available at present, we optimized and validated an automated
serum immune turbidimetric test for urine measurements. Furthermore, our aim was to investigate u-CYSC
concentrations in diseases which can be accompanied by acute or chronic kidney injury.

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